Article

High-sensitivity monitoring of ctDNA by patient-specific sequencing panels and integration of variant reads

2019-09-11

Abstract excerpt

Circulating tumor-derived DNA (ctDNA) can be used to monitor cancer dynamics noninvasively. Patients with small tumors have few copies of ctDNA in plasma, resulting in limited sensitivity to detect low-volume or residual disease. We show that sampling limitations can be overcome and sensitivity for ctDNA detection can be improved by massively parallel sequencing when hundreds to thousands of mutations are identifi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 499d8292-12d4-51b6-b933-6911e7fe298f
DOI: 10.1101/759399

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-sensitivity monitoring of ctDNA by patient-specific sequencing panels and integration of variant readsDOI 10.1101/759399Read

ctDNA monitoring using patient-specific sequencing and integration of variant reads.Semantic proximity Read

Monitoring trace levels of ctDNA using integration of variant readsSemantic proximity Read

Whole genome error-corrected sequencing for sensitive circulating tumor DNA cancer monitoringSemantic proximity Read

In-depth assessment of BRAF, NRAS, KRAS, EGFR, and PIK3CA mutations on cell-free DNA in the blood of melanoma patients receiving immune checkpoint inhibitionSemantic proximity Read

Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment.Semantic proximity Read

Personalized Cancer Monitoring Assay for the Detection of ctDNA in Patients with Solid Tumors.Semantic proximity Read

Machine learning guided signal enrichment for ultrasensitive plasma tumor burden monitoringSemantic proximity Read

GeneBits: ultra-sensitive tumour-informed ctDNA monitoring of treatment response and relapse in cancer patients.Semantic proximity Read

ctDNA detection by personalised assays in early-stage NSCLCSemantic proximity Read

Systematic benchmarking of multi-modal approaches for tumor-naïve ctDNA detection and quantificationSemantic proximity Read

Concordance between whole exome sequencing of circulating tumor DNA and tumor tissue.Semantic proximity Read

Mutation analysis in individual circulating tumor cells depicts intratumor heterogeneity in melanoma.Semantic proximity Read