Mutation analysis in individual circulating tumor cells depicts intratumor heterogeneity in melanoma.

doi:10.1038/s44321-024-00082-6

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Article

Mutation analysis in individual circulating tumor cells depicts intratumor heterogeneity in melanoma.

EMBO molecular medicine - 1 Jul 2024

Sementsov Mark, Ott Leonie, Kött Julian, Sartori Alexander, Lusque Amelie, Degenhardt Sarah, Segier Bertille, Heidrich Isabel, Volkmer Beate, Greinert Rüdiger, Mohr Peter, Simon Ronald, Stadler Julia-Christina, Irwin Darryl, Koch Claudia, Andreas Antje, Deitert Benjamin, Thewes Verena, Trumpp Andreas, Schneeweiss Andreas, Belloum Yassine, Peine Sven, Wikman Harriett, Riethdorf Sabine, Schneider Stefan W, Gebhardt Christoffer, Pantel Klaus, Keller Laura

Abstract excerpt

Circulating tumor DNA (ctDNA) is the cornerstone of liquid biopsy diagnostics, revealing clinically relevant genomic aberrations from blood of cancer patients. Genomic analysis of single circulating tumor cells (CTCs) could provide additional insights into intra-patient heterogeneity, but it requires whole-genome amplification (WGA) of DNA, which might introduce bias. Here, we describe a novel approach based on...

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Identifiers

PMID: 38898234
DOI: 10.1038/s44321-024-00082-6
PMCID: PMC11250829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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