Article
Concordance between whole exome sequencing of circulating tumor DNA and tumor tissue.
PloS one - 1 Jan 2023
Leenanitikul Julanee, Chanchaem Prangwalai, Mankhong Suwanan, Denariyakoon Sikrit, Fongchaiya Valla, Arayataweegool Areeya, Angspatt Pattama, Wongchanapai Ploytuangporn, Prapanpoj Verayuth, Chatamra Kris, Pisitkun Trairak, Sriswasdi Sira, Wongkongkathep Piriya
Abstract excerpt
Next generation sequencing of circulating tumor DNA (ctDNA) has been used as a noninvasive alternative for cancer diagnosis and characterization of tumor mutational landscape. However, low ctDNA fraction and other factors can limit the ability of ctDNA analysis to capture tumor-specific and actionable variants. In this study, whole-exome sequencings (WES) were performed on paired ctDNA and tumor biopsy in 15...
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