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Article

Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America - 16 Feb 1999

Kurimasa A, Ouyang H, Dong L J, Wang S, Li X, Cordon-Cardo C, Chen D J, Li G C

Abstract excerpt

The DNA-dependent protein kinase (DNA-PK) consists of a heterodimer DNA-binding complex, Ku70 and Ku80, and a large catalytic subunit, DNA-PKcs. To examine the role of DNA-PKcs in lymphocyte development, radiation sensitivity, and tumorigenesis, we disrupted the mouse DNA-PKcs by homologous recombination. DNA-PKcs-null mice exhibit neither growth retardation nor a high frequency of T cell lymphoma development,...

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Source

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Identifiers

PMID: 9990036
DOI: 10.1073/pnas.96.4.1403
PMCID: PMC15475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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