Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rational design, structure, and biological evaluation of cyclic peptides mimicking the vascular endothelial growth factor.

Journal of medicinal chemistry - 18 Oct 2007

Goncalves Victor, Gautier Benoit, Coric Pascale, Bouaziz Serge, Lenoir Christine, Garbay Christiane, Vidal Michel, Inguimbert Nicolas

Abstract excerpt

Angiogenesis is the development of a novel vascular network from a pre-existing structure. Blocking angiogenesis is an attractive strategy to inhibit tumor growth and metastasis formation. Based on structural and mutagenesis data, we have developed novel cyclic peptides that mimic, simultaneously, two regions of the VEGF crucial for the interaction with the VEGF receptors. The peptides, displaying the best...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis Inhibitors
Share to Capillaries

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Laminin

Share to Molecular Mimicry

Share to Peptides, Cyclic

Share to Quantitative Structure-Activity Relationship

Share to Umbilical Veins

Share to Vascular Endothelial Growth Factor Receptor-1

Source

Identifiers

PMID: 17900101
DOI: 10.1021/jm0706970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rational design, structure, and biological evaluation of cyclic peptides mimicking the vascular endothelial growth factor.PMID 17900101Read ↗

The peptidomimetic Vasotide targets two retinal VEGF receptors and reduces pathological angiogenesis in murine and nonhuman primate models of retinal diseaseSemantic proximity Read ↗

Computer-guided design of Z domain peptides with improved inhibition of VEGFSemantic proximity Read ↗

Synthetic disulfide-bridged cyclic peptides mimic the anti-angiogenic actions of chondromodulin-I.Semantic proximity Read ↗

Human endostatin-derived synthetic peptides possess potent antiangiogenic properties in vitro and in vivoSemantic proximity Read ↗

Angiogenesis: A Target for Cancer TherapySemantic proximity Read ↗

Recent developments in the inhibition of angiogenesis: examples from studies on platelet factor-4 and the VEGF/VEGFR systemSemantic proximity Read ↗

Therapeutics targeting angiogenesis: genetics and epigenetics, extracellular miRNAs and signaling networks (Review).Semantic proximity Read ↗

VEGF-A: a critical regulator of blood vessel growthSemantic proximity Read ↗

Vascular Endothelial Growth Factor Signaling Pathways: Therapeutic PerspectiveSemantic proximity Read ↗

EG-VEGF and Bv8. a novel family of tissue-selective mediators of angiogenesis, endothelial phenotype, and function.Semantic proximity Read ↗

Modulation of Host Angiogenesis as a Microbial Survival Strategy and Therapeutic TargetSemantic proximity Read ↗

Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.