[RNA splicing dysregulation in hematological malignancies].

Abstract excerpt

Recurrent mutations in genes encoding key splicing factors, SF3B1, SRSF2, U2AF1, and ZRSR2 have been found in a variety of cancers, particularly in hematologic malignancies, including myelodysplastic syndromes, chronic myelomonocytic leukemia, acute myeloid leukemia, and chronic lymphocytic leukemia. Global mis-splicing of mRNAs targeted by aberrant splicing factors partly contributes to leukemogenesis through...

Topics

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• Hematologic Neoplasms
• Leukemia, Myeloid, Acute
• Mutation
• RNA, Messenger
• RNA Splicing