Article

Imputed Genomic Data Reveals a Moderate Effect of Low Frequency Variants to the Heritability of Complex Human Traits

2019-12-19

Abstract excerpt

The genetic architecture of complex human traits remains largely unknown. The distribution of heritability across the minor allele frequency (MAF) spectrum for a trait will be a function of the MAF of its causal variants and their effect sizes. Assumptions about these relationships underpin the tools used to estimate heritability. We examine the performance of two widely used tools, Haseman-Elston (HE) Regression...

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Literature Corpus work: 493859b0-b9a9-5ec8-ba4f-5b8006d51201
DOI: 10.1101/2019.12.18.879916

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Imputed Genomic Data Reveals a Moderate Effect of Low Frequency Variants to the Heritability of Complex Human TraitsDOI 10.1101/2019.12.18.879916Read

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