ERK1 Is a Regulatory Kinase Coordinating ERK2 Function in Colon Adenocarcinoma

Abstract excerpt

ERK1/2 phosphorylation is frequently downregulated in the early phase of colon tumorigenesis with subsequent activation of ERK5. In the current work, we studied the advantage of ERK1/2 downregulation for tumor growth by dissecting the individual functions of ERK1 and ERK2. The patient sample data demonstrated decreased ERK1/2 phosphorylation in the early phase of tumorigenesis followed by upregulation of the phosp...

Topics

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• Colorectal Neoplasms
• Disease Progression
• Fungal Biology and Applications
• Genes, ras
• MAP Kinase Signaling System
• Mitogen-Activated Protein Kinase 1
• Neoplasm Staging
• Phosphorylation

Identifiers and source

Literature Corpus work

4908346b-763d-5748-89ec-6d3cdf3cbcd5

DOI

10.20944/preprints202312.0533.v1