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Dual role of sprouty2 as an inhibitor of RAS/ERK-driven proliferation and a promoter of cancer invasion in KRAS wild-type colorectal cancer.

Molecular carcinogenesis - 1 Jul 2023

Lee Chung-Ta, Chu Chien-An, Wang Yu-Ming, Wang Yi-Wen, Chen Yi-Lin, Ho Chung-Liang, Yeh Yu-Min, Lin Peng-Chan, Lin Bo-Wen, Chen Po-Chuan, Chen Shang-Hung, Chan Ren-Hao, Chang Chen, Chow Nan-Haw

Abstract excerpt

Sprouty2 (SPRY2) is known to inhibit the RAS/MAPK/ERK pathway, and is a potential study target for cancer. The effect of SPRY2 in colorectal cancer (CRC) and whether it is influenced by KRAS mutation are not known. We manipulated SPRY2 gene expression and used an activating KRAS-mutant plasmid to determine its effect on CRC cell function in vitro and/or in vivo. We performed SPRY2 immunohistochemical staining in...

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Caco-2 Cells
Cell Line, Tumor
Cell Proliferation
Cohort Studies
Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intracellular Signaling Peptides and Proteins

Membrane Proteins

Proto-Oncogene Proteins p21(ras)

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PMID: 37014154
DOI: 10.1002/mc.23537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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