Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells

2 Feb 2010

Abstract excerpt

The molecular heterogeneity of human cancer cells at the level of signaling protein activities remains poorly understood. Using a panel of 64 colorectal (CRC) cancer cell lines the activity status of the MAP kinases Erk1 and Erk2 was investigated. Erk1/2 activity varied greatly within the CRC cell line panel and was not detectably associated with the speed of cell growth in 10 CRC lines analyzed. As expected,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Melanoma and MAPK Pathways
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20181064
DOI: 10.1186/1478-811x-8-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cellsPMID 20181064Read ↗

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epitheliumSemantic proximity Read ↗

KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.Semantic proximity Read ↗

Oncogenic Effects of High MAPK Activity in Colorectal Cancer Mark Progenitor Cells and Persist Irrespective of RAS Mutations.Semantic proximity Read ↗

ERK1 Is a Regulatory Kinase Coordinating ERK2 Function in Colon AdenocarcinomaSemantic proximity Read ↗

ERKs in cancer: friends or foes?Semantic proximity Read ↗

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epitheliumSemantic proximity Read ↗

Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.Semantic proximity Read ↗

Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.Semantic proximity Read ↗

KRAS mutation-independent downregulation of MAPK/PI3K signaling in colorectal cancer.Semantic proximity Read ↗

Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer.Semantic proximity Read ↗

Role of ERK1/2 and p38 Protein Kinases in Tumors: Biological Insights and Clinical ImplicationsSemantic proximity Read ↗

ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.