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Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

8 Aug 2022

Abstract excerpt

MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic and epigenetic changes, signaling cascades are altered in a variety of diseases, including cancer. Extant studies on the homeostatic and pathologic behavior of MAPK signaling have been conducted; however,...

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PMID: 35941592
DOI: 10.1186/s12935-022-02666-z

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