Article

eIF2Bα subcellular localisation – a potential link between translation initiation and stress granule formation?

2025-12-21

Abstract excerpt

The eukaryotic initiation factor 2B (eIF2B) complex is a guanine nucleotide exchange factor (GEF) that regulates translation initiation and is central to the integrated stress response (ISR). eIF2B exists as a decamer composed of catalytic (γ, ε) and regulatory (α, β, δ) subunits, which localise to cytoplasmic foci termed eIF2B bodies. While eIF2B bodies exhibit dynamic changes during stress, the role of individua...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 49016331-e1df-529a-9816-887f5035cfaf
DOI: 10.64898/2025.12.19.695478

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

eIF2Bα subcellular localisation – a potential link between translation initiation and stress granule formation?DOI 10.64898/2025.12.19.695478Read

eIF2B localisation and its regulation during the integrated stress response is cell type specificSemantic proximity Read

Large G3BP-induced granules trigger eIF2α phosphorylation.Semantic proximity Read

EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.Semantic proximity Read

Analysis of eIF2B bodies and their relationships with stress granules and P-bodies.Semantic proximity Read

Sumoylation of eIF4A2 affects stress granule formation.Semantic proximity Read

Optimisation of immunocytochemistry methodology for the detection of endogenous eIF2B localised fociSemantic proximity Read

Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.Semantic proximity Read

Neuronal Regulation of eIF2α Function in Health and Neurological Disorders.Semantic proximity Read

Inhibition of Ribosome Recruitment Induces Stress Granule Formation Independently of Eukaryotic Initiation Factor 2α PhosphorylationSemantic proximity Read

Intracellular energy controls dynamics of stress-induced ribonucleoprotein granulesSemantic proximity Read

Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease.Semantic proximity Read

eIF2B: recent structural and functional insights into a key regulator of translation.Semantic proximity Read