Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease.

The Journal of biological chemistry - 1 Jan 2000

Norris Karl, Hodgson Rachel E, Dornelles Tawni, Allen K Elizabeth, Abell Ben M, Ashe Mark P, Campbell Susan G

Abstract excerpt

Eukaryotic initiation factor 2B (eIF2B) serves as a vital control point within protein synthesis and regulates translation initiation in response to cellular stress. Mutations within eIF2B result in the fatal disease, leukoencephalopathy with vanishing white matter (VWM). Previous biochemical studies on VWM mutations have illustrated that changes in the activity of eIF2B poorly correlate with disease severity....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis
Share to Eukaryotic Initiation Factor-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukoencephalopathies

Share to Mutagenesis, Site-Directed

Share to Mutation, Missense

Share to Protein Biosynthesis

Share to Protein Processing, Post-Translational

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 33334879
DOI: 10.1074/jbc.RA120.014956
PMCID: PMC7948505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease.PMID 33334879Read ↗

Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways.Semantic proximity Read ↗

Analysis of eIF2B bodies and their relationships with stress granules and P-bodies.Semantic proximity Read ↗

Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter.Semantic proximity Read ↗

EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.Semantic proximity Read ↗

eIF2B: recent structural and functional insights into a key regulator of translation.Semantic proximity Read ↗

Severity of vanishing white matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes.Semantic proximity Read ↗

Biochemical effects of mutations in the gene encoding the alpha subunit of eukaryotic initiation factor (eIF) 2B associated with Vanishing White Matter disease.Semantic proximity Read ↗

eIF2B, a mediator of general and gene-specific translational control.Semantic proximity Read ↗

The Translational Landscape of Reactive Astrocytes Reveals the Impact of eIF2B-mediated Dysregulation in VWM DiseaseSemantic proximity Read ↗

Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.Semantic proximity Read ↗

eIF2B Activator Rescues Neonatal Lethality of an eIF2Bα Sugar Phosphate Binding Mutation Associated with Vanishing White Matter DiseaseSemantic proximity Read ↗

Identification of ten novel mutations in patients with eIF2B-related disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.