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Article

eIF2B: recent structural and functional insights into a key regulator of translation.

Biochemical Society transactions - 1 Dec 2015

Wortham Noel C, Proud Christopher G

Abstract excerpt

The eukaryotic translation initiation factor (eIF) eIF2B is a key regulator of mRNA translation, being the guanine nt exchange factor (GEF) responsible for the recycling of the heterotrimeric G-protein, eIF2, which is required to allow translation initiation to occur. Unusually for a GEF, eIF2B is a multi-subunit protein, comprising five different subunits termed α through ε in order of increasing size. eIF2B is...

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PMID: 26614666
DOI: 10.1042/BST20150164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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eIF2B: recent structural and functional insights into a key regulator of translation.PMID 26614666Read ↗

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