Article
Whisper mutations: cryptic messages within the genetic code.
Oncogene - 21 Jul 2016
Fåhraeus R, Marin M, Olivares-Illana V
Abstract excerpt
Recent years have seen a great expansion in our understandings of how silent mutations can drive a disease and that mRNAs are not only mere messengers between the genome and the encoded proteins but also encompass regulatory activities. This review focuses on how silent mutations within open reading frames can affect the functional properties of the encoded protein. We describe how mRNAs exert control of cell...
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