Article

Palantir characterizes cell fate continuities in human hematopoiesis

2018-08-05

Abstract excerpt

Recent studies using single cell RNA-seq (scRNA-seq) data derived from differentiating systems have raised fundamental questions regarding the discrete vs continuous nature of both differentiation and cell fate. Here we present Palantir, an algorithm that models trajectories of differentiating cells, which treats cell-fate as a probabilistic process, and leverages entropy to measure the changing nature of cell pla...

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Literature Corpus work: 489db616-61a4-5456-a3d2-ad24e8f2fa07
DOI: 10.1101/385328

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