Article

Topographer Reveals Dynamic Mechanisms of Cell Fate Decisions from Single-Cell Transcriptomic Data

2018-01-21

Abstract excerpt

Cell fate decisions play a pivotal role in development but technologies for dissecting them are limited. We developed a multifunction new method, Topographer to construct a ‘quantitative’ Waddington’s landscape of single-cell transcriptomic data. This method is able to identify complex cell-state transition trajectories and to estimate complex cell-type dynamics characterized by fate and transition probabilities....

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Literature Corpus work: a8fbb5dd-fea3-5604-862f-3b149e19d9c4
DOI: 10.1101/251207

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