Article

Mutational signature decomposition with deep neural networks reveals origins of clock-like processes and hypoxia dependencies

2023-12-08

Abstract excerpt

DNA mutational processes generate patterns of somatic and germline mutations. A multitude of such mutational processes has been identified and linked to biochemical mechanisms of DNA damage and repair. Cancer genomics relies on these so-called mutational signatures to classify tumours into subtypes, navigate treatment, determine exposure to mutagens, and characterise the origin of individual mutations. Yet, state-...

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Literature Corpus work: 09e8e919-414d-5a79-a199-7d94c425e3d8
DOI: 10.1101/2023.12.06.570467

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