Article

Harnessing synergy between BCL6 and PI3Kδ to generate a new mouse model for lymphoma

2020-01-01

Abstract excerpt

Signalling through the phosphoinositide 3-kinase (PI3K) pathway is critical for immune cell development and function. Patients with a gain of function mutation in PI3Kδ, called Activated PI3Kδ syndrome (APDS) commonly develop autoimmunity, lymphoproliferation, and lymphoma. PIK3CD is also among the most commonly mutated genes in Diffuse Large B cell lymphoma (DLBCL). The most commonly studied mouse model of DLBCL...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64d86b00-5cef-52a4-b0dd-279d09c47b68
DOI: 10.17863/cam.58234

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Harnessing synergy between BCL6 and PI3Kδ to generate a new mouse model for lymphomaDOI 10.17863/cam.58234Read

PI3Kδ inhibition causes feedback activation of PI3Kα in the ABC subtype of diffuse large B-cell lymphomaSemantic proximity Read

T cell phenotyping of a mouse model of Activated PI3Kdelta SyndromeSemantic proximity Read

Activated PI3Kinase Delta Syndrome—A Multifaceted DiseaseSemantic proximity Read

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2.Semantic proximity Read

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.Semantic proximity Read

Germline-activating mutations in PIK3CD compromise B cell development and function.Semantic proximity Read

Activated PI3 Kinase Delta Syndrome: From Genetics to Therapy.Semantic proximity Read

p110δ PI3 kinase pathway: emerging roles in cancerSemantic proximity Read

PI3Kδ inhibitor idelalisib in combination with BTK inhibitor ONO/GS-4059 in diffuse large B cell lymphoma with acquired resistance to PI3Kδ and BTK inhibitors.Semantic proximity Read

Activated PIK3CD drives innate B cell expansion yet limits B cell–intrinsic immune responsesSemantic proximity Read

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.Semantic proximity Read

The human <i>BCL6</i> transgene promotes the development of lymphomas in the mouseSemantic proximity Read