Back to search

Article

3D Endothelium-on-a-Chip Reveals Cx43/LDHA Axis as a Driver of Endothelial Barrier Dysfunction in Diabetic Kidney Disease

2025-05-23

Abstract excerpt

<h4>ABSTRACT</h4> Endothelial dysfunction is a key pathological feature of diabetic kidney disease (DKD), characterized by increased vascular leakiness and altered metabolic signaling. In this study, we investigated how diabetic conditions affect endothelial barrier integrity and identified the molecular mechanisms contributing to this dysfunction. Using a 3D microfluidic model that recapitulates in vivo vascular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
485128b3-c5e9-5126-b88d-c27324d59a50
DOI
10.1101/2025.05.19.654627
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
3D Endothelium-on-a-Chip Reveals Cx43/LDHA Axis as a Driver of Endothelial Barrier Dysfunction in Diabetic Kidney DiseaseDOI 10.1101/2025.05.19.654627
Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney diseaseSemantic proximity
Post-ischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysisSemantic proximity
Deep multi-omic profiling reveals extensive mitochondrial remodeling driven by glycemia in early diabetic kidney diseaseSemantic proximity
A diabetic <i>milieu</i> increases cellular susceptibility to SARS-CoV-2 infections in engineered human kidney organoids and diabetic patientsSemantic proximity
Renal microvascular damaged in diabetes mellitus with hyperlipidemia through the regulation of MAMs by PACS2 in endothelial cellSemantic proximity
Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease.Semantic proximity
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cellsSemantic proximity
Glomerular endothelial cell heterogeneity in Alport syndromeSemantic proximity
Impaired renal gluconeogenesis is a major determinant of acute kidney injury associated mortalitySemantic proximity
Elevated glucose in kidney organoids induces tissue-intrinsic inflammation driving epithelial detachmentSemantic proximity
Kidney single-cell transcriptomes uncover SGLT2i-induced metabolic reprogramming via restoring glycolysis and fatty acid oxidationSemantic proximity
PTTG1-Mediated Pericyte Dysfunction Drives Diabetes-Induced Microvascular DysfunctionSemantic proximity
Select a neighboring publication to make it the new centre.