Article

Deep multi-omic profiling reveals extensive mitochondrial remodeling driven by glycemia in early diabetic kidney disease

2023-10-26

Abstract excerpt

<h4>Summary</h4> Changes in mitochondrial energy metabolism are thought to be central to the development of diabetic kidney disease (DKD); however, whether this response is explicitly driven by systemic glucose concentrations remains unknown. Here, we show that titrating blood glucose concentrations in vivo directly impacts mitochondrial morphology and bioenergetics and remodels the mitochondrial proteome in the...

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Literature Corpus work: 7cabd275-2907-56c3-9abe-148ba541b943
DOI: 10.1101/2023.10.26.564228

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