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A T-cell intrinsic Role for <i>APOL1</i> Risk Alleles in Allograft Rejection

2025-07-18

Abstract excerpt

African Americans have an increased risk of kidney disease due to exonic variants in Apolipoprotein-L1 (G1 and G2). These prevalent variants have also been linked with kidney rejection, but outside of association with African ancestry, underpinning causal mechanisms are unknown. We investigated T-cell function using transgenic mice with physiologic expression of wild type (G0-), G1-, or G2-APOL1. Mice with variant...

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Literature Corpus work
484f121e-7c51-50dc-97cc-ef956dc4f5d2
DOI
10.1101/2025.07.14.664793
Open publication

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A T-cell intrinsic Role for <i>APOL1</i> Risk Alleles in Allograft RejectionDOI 10.1101/2025.07.14.664793
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