Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes.

doi:10.1172/JCI146643

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Article

Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes.

The Journal of clinical investigation - 15 Nov 2021

Zhang Zhongyang, Sun Zeguo, Fu Jia, Lin Qisheng, Banu Khadija, Chauhan Kinsuk, Planoutene Marina, Wei Chengguo, Salem Fadi, Yi Zhengzi, Liu Ruijie, Cravedi Paolo, Cheng Haoxiang, Hao Ke, O'Connell Philip J, Ishibe Shuta, Zhang Weijia, Coca Steven G, Gibson Ian W, Colvin Robert B, He John Cijiang, Heeger Peter S, Murphy Barbara, Menon Madhav C

Abstract excerpt

Apolipoprotein L1 (APOL1) risk alleles in donor kidneys associate with graft loss, but whether recipient risk allele expression affects transplant outcomes is unclear. To test whether recipient APOL1 risk alleles independently correlate with transplant outcomes, we analyzed genome-wide SNP genotyping data on donors and recipients from 2 kidney transplant cohorts: Genomics of Chronic Allograft Rejection (GOCAR)...

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Identifiers

PMID: 34499625
DOI: 10.1172/JCI146643
PMCID: PMC8592534

Genes

APOL1
CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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