Article
APOL1 risk alleles modulate T cell receptor signaling to promote allograft rejection.
The Journal of clinical investigation - 3 Aug 2026
Pell John, Tanvir E M, Sun Zeguo, Chernova Irene, Reghuvaran Anand, Nagata Soichiro, Guerra Mateus T, Choi John, Al Chaar Soltan, Mizuno Hiroki, Dong Ke, Tian Xin, Ishibe Reika, Franchin Barbara, Cravedi Paolo, Kumar Ashwani, Barsotti Gabriel, Shi Hongmei, De Kumar Bony, Smithson Shinobu, Song Wenzhi, He John Cijiang, Chong Anita S, Pober Jordan S, Somlo Stefan, Gibson Ian W, Popik Waldemar, Zhang Zhongyang, Craft Joseph, Azzi Jamil, Murakami Naoka, Ishibe Shuta, Heeger Peter S, Menon Madhav C
Abstract excerpt
The exonic variants G1 and G2 in apolipoprotein-L1 (APOL1) are linked to an increased risk of kidney disease as well as kidney transplant rejection. Outside of the association of these prevalent variants with African ancestry, the underpinning causal mechanisms for rejection are unknown. We investigated T cell function using transgenic mice with physiologic expression of WT (G0), G1 APOL1 (G1), or G2 APOL1 (G2)....
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