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Article

Apolipoprotein L1 and Kidney Disease in African Americans.

Trends in endocrinology and metabolism: TEM - 1 Apr 2016

Friedman David J, Pollak Martin R

Abstract excerpt

Genetic variants in the Apolipoprotein L1 (APOL1) gene cause high rates of kidney disease in African Americans. These variants, found only in individuals with recent African ancestry, confer enhanced innate immunity against African trypanosomes. Although they are among the most powerful disease-causing common variants discovered to date, we are just beginning to understand how they promote kidney injury. Since...

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Source

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Identifiers

PMID: 26947522
DOI: 10.1016/j.tem.2016.02.002
PMCID: PMC4811340

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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