Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOL1 risk variants in kidney transplantation: a modulation of immune cell function.

The Journal of clinical investigation - 15 Nov 2021

Malone Andrew F

Abstract excerpt

APOL1 G1 and G2 variants are established risk factors for nondiabetic kidney disease. The presence of two APOL1 risk variants in donor kidneys negatively impacts kidney allograft survival. Because of evolutionary pressure, the APOL1 risk variants have become common in people from Africa and in those with recent African ancestry. APOL1 risk variant proteins are expressed in kidney cells and can cause toxicity to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein L1
Share to Genotype
Share to Kidney Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Transplantation

Share to Risk Factors

Share to Tissue Donors

Source

Open in PubMed Open full text

Identifiers

PMID: 34779415
DOI: 10.1172/JCI154676
PMCID: PMC8592540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOL1 risk variants in kidney transplantation: a modulation of immune cell function.PMID 34779415Read ↗

APOL1 risk alleles modulate T cell receptor signaling to promote allograft rejection.Semantic proximity Read ↗

APOL1 Risk Alleles and Outcomes in Kidney Transplantation: Enter the Recipient.Semantic proximity Read ↗

Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes.Semantic proximity Read ↗

A T-cell intrinsic Role for <i>APOL1</i> Risk Alleles in Allograft RejectionSemantic proximity Read ↗

The evolving science of apolipoprotein-L1 and kidney disease.Semantic proximity Read ↗

The APOL1 gene and kidney transplantation: a review article.Semantic proximity Read ↗

Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodesSemantic proximity Read ↗

Integrating APOL1 Gene Variants Into Renal Transplantation: Considerations Arising From the American Society of Transplantation Expert Conference.Semantic proximity Read ↗

Apolipoprotein L1 Gene Effects on Kidney Transplantation.Semantic proximity Read ↗

Mechanisms of Injury in APOL1-associated Kidney DiseaseSemantic proximity Read ↗

Apolipoprotein L1 and mechanisms of kidney disease susceptibility.Semantic proximity Read ↗

The impact of APOL1, CAV1, and ABCB1 gene variants on outcomes in kidney transplantation: donor and recipient effects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.