Article

Astrocyte-driven small vessel disease is an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer’s disease

2026-07-22

Abstract excerpt

Cerebral Small vessel disease (cSVD) is a prevalent feature of Alzheimer’s disease (AD) pathology. Whether this pathology is a late consequence of amyloid and tau accumulation or an early, direct effect of PSEN1 dysfunction has remained unresolved. We found that it is more severe in familial AD (FAD) caused by E280A mutation in presenilin 1 (PSEN1). These cases present with a distinctive proteomic signature, assoc...

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Literature Corpus work: 483f1b3f-c6f0-5e5c-8a6c-ecd61ff4ace3
DOI: 10.64898/2026.07.17.739026

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Astrocyte-driven small vessel disease is an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer’s diseaseDOI 10.64898/2026.07.17.739026Read

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