Article
Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival
2021-06-09
Abstract excerpt
Genetic alterations in cancer cells trigger oncogenic transformation, a process largely mediated by the dysregulation of kinase and transcription factor (TF) activities. While the mutational profiles of thousands of tumours has been extensively characterized, the measurements of protein activities has been technically limited until recently. We compiled public data of matched genomics and (phospho)proteomics measu...
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Identifiers and source
- Literature Corpus work
- 483dc1ff-a700-5eec-86b2-6c950d0a8607
- DOI
- 10.1101/2021.06.09.447741