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Article

Pancancer modelling predicts the context-specific impact of somatic mutations on transcriptional programs.

Nature communications - 31 Jan 2017

Osmanbeyoglu Hatice U, Toska Eneda, Chan Carmen, Baselga José, Leslie Christina S

Abstract excerpt

Pancancer studies have identified many genes that are frequently somatically altered across multiple tumour types, suggesting that pathway-targeted therapies can be deployed across diverse cancers. However, the same 'actionable mutation' impacts distinct context-specific gene regulatory programs and signalling networks-and interacts with different genetic backgrounds of co-occurring alterations-in different...

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PMID: 28139702
DOI: 10.1038/ncomms14249
PMCID: PMC5290314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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