Article

Efficient base editing and development in human embryos without chromosomal alterations

2026-06-01

Abstract excerpt

<h4>ABSTRACT</h4> Cas9-based tools enable the introduction of genetic lesions to investigate DNA repair outcomes and edit the genome at disease-relevant loci. DNA double-strand breaks (DSBs) induced by CRISPR/Cas9 result in frequent aneuploidy and large deletions, revealing a repair deficiency in early human embryos and limiting the clinical application of this technology. Here we evaluated the DNA repair outcome...

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Literature Corpus work: 69c4ac1a-9bd3-53c8-975b-69dba40f3d25
DOI: 10.64898/2026.05.30.728989

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