Article

Intrinsically disordered bHLH family member TCF4 drives LLPS in a DNA-dependent manner

2025-06-19

Abstract excerpt

Transcription factor 4 (TCF4), a basic helix-loop-helix (bHLH) protein, plays a critical role in neurodevelopment and is genetically linked to disorders such as Pitt-Hopkins syndrome (PTHS) and schizophrenia. While TCF4 is known to function through sequence-specific DNA binding, the influence of its intrinsically disordered regions (IDRs) on its molecular behavior remains scattered. The TCF4 deletion mutant, lacki...

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Literature Corpus work: 47f8e510-d20f-524b-a45c-d0b01e6122a8
DOI: 10.1101/2025.06.18.660356

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