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Complete definition of how antibodies used to prevent RSV are affected by F mutations

2026-02-12

Abstract excerpt

New antibodies targeting the F protein of RSV have substantially reduced infant hospitalizations. However, viral resistance is a concern: one antibody failed clinical trials due to a resistant strain, and sporadic resistance mutations to the most widely used antibody (nirsevimab) have been identified. Here we define how RSV F mutations affect antibody neutralization. We first provide a biophysical model of how the...

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Literature Corpus work
a11abd6b-7ef6-53d5-8cae-33b05d30daad
DOI
10.64898/2026.02.12.705519
Open publication

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Complete definition of how antibodies used to prevent RSV are affected by F mutationsDOI 10.64898/2026.02.12.705519
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