Characterization of epitopes on the rabies virus glycoprotein by selection and analysis of escape mutants.

doi:10.1016/j.virusres.2016.04.019

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Article

Characterization of epitopes on the rabies virus glycoprotein by selection and analysis of escape mutants.

Virus research - 15 Jul 2016

Fallahi Firouzeh, Wandeler Alexander I, Nadin-Davis Susan A

Abstract excerpt

The glycoprotein (G) is the only surface protein of the lyssavirus particle and the only viral product known to be capable of eliciting the production of neutralizing antibodies. In this study, the isolation of escape mutants resistant to monoclonal antibody (Mab) neutralization was attempted by a selection strategy employing four distinct rabies virus strains: the extensively passaged Evelyn Rokitnicki Abelseth...

Topics

Amino Acid Substitution
Animals
Antibodies, Monoclonal
Antibodies, Neutralizing
Antibodies, Viral
Antigen-Antibody Complex
Antigens, Viral
Epitope Mapping
Epitopes
Female
Gene Expression
Glycoproteins
Immune Evasion
Mice
Mutation
Neutralization Tests
Rabies
Rabies virus

Source

Open in PubMed

Identifiers

PMID: 27132040
DOI: 10.1016/j.virusres.2016.04.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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