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Article

Premature Activation of the HIV-1 Protease Is Influenced by Polymorphisms in the Hinge Region.

Viruses - 26 May 2024

Tabler Caroline O, Wegman Sarah J, Alhusaini Najwa, Lee Nicole F, Tilton John C

Abstract excerpt

HIV-1 protease inhibitors are an essential component of antiretroviral therapy. However, drug resistance is a pervasive issue motivating a persistent search for novel therapies. Recent reports found that when protease activates within the host cell's cytosol, it facilitates the pyroptotic killing of infected cells. This has led to speculation that promoting protease activation, rather than inhibiting it, could...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38932142
DOI: 10.3390/v16060849
PMCID: PMC11209583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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