Article

Direct cleavage of human NLRP1 by enteroviral 3C protease triggers inflammasome activation in airway epithelium

2020-10-14

Abstract excerpt

Viruses pose a constant threat to human health. As a result our innate immune system has evolved multiple strategies to detect the presence of intracellular viral ‘pathogen-associated molecular patterns’ (PAMPs) ( 1 ). The full repertoire of human immune sensors and their PAMP ligands are not completely understood. Here we report that human NLRP1 senses and is activated by 3C proteases (3Cpros) of enteroviruses....

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Literature Corpus work: dfe2bbc4-ba64-57b4-889a-e6801f1d2152
DOI: 10.1101/2020.10.14.325076

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