Article

Co-localization of Conditional eQTL and GWAS Signatures in Schizophrenia

2017-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Causal genes and variants within genome-wide association study (GWAS) loci can be identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and determining which SNPs underlie both GWAS and eQTL signals. Most analyses, however, consider only the marginal eQTL signal, rather than dissecting this signal into multiple independent eQTL for each gene. Here we show that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0267fd0a-973f-50eb-be53-f03ec9013a65
DOI: 10.1101/129429

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Co-localization of Conditional eQTL and GWAS Signatures in SchizophreniaDOI 10.1101/129429Read

Co-expression-based models improve eQTL predictions and highlight novel transcriptome-wide genes associated with schizophreniaSemantic proximity Read

Co-expression-based models improve eQTL predictions for transcriptome-wide association studies and highlight new schizophrenia-associated genes.Semantic proximity Read

Trans-ethnic eQTL meta-analysis of human brain reveals regulatory architecture and candidate causal variants for brain-related traitsSemantic proximity Read

Trans-ethnic eQTL meta-analysis of human brain reveals regulatory architecture and candidate causal variants for brain-related traitsSemantic proximity Read

Cascading Epigenomic Analysis for Identifying Disease Genes from the Regulatory Landscape of GWAS VariantsSemantic proximity Read

Illuminating links between cis-regulators and trans-acting variants in the human prefrontal cortex.Semantic proximity Read

A Bayesian Framework for Multiple Trait Colocalization from Summary Association StatisticsSemantic proximity Read

Isoform-level transcriptome-wide association uncovers extensive novel genetic risk mechanisms for neuropsychiatric disorders in the human brainSemantic proximity Read

The impact of common variants on gene expression in the human brain: from RNA to protein to schizophrenia riskSemantic proximity Read

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regionsSemantic proximity Read

Illuminating links between cis-regulators and trans-acting variants in the human prefrontal cortexSemantic proximity Read

CCmed: cross-condition mediation analysis for identifying robust trans-eQTLs and assessing their effects on human traitsSemantic proximity Read