Article

The Tryptophan Metabolizing Enzyme Indoleamine 2,3-Dioxygenase 1 Regulates Polycystic Kidney Disease Progression

2022-05-04

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD), the most common monogenic nephropathy, is characterized by phenotypic variability exceeding genic effects. Dysregulated metabolism and immune cell function are key disease modulators. The tryptophan metabolites, kynurenines, produced through IDO1, are known immunomodulators. Here, we study the role of tryptophan metabolism in PKD using an orthologous disease mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 373fb862-ef71-5a2b-9328-795187ad409c
DOI: 10.1101/2022.05.04.490641

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Tryptophan Metabolizing Enzyme Indoleamine 2,3-Dioxygenase 1 Regulates Polycystic Kidney Disease ProgressionDOI 10.1101/2022.05.04.490641Read

Anti-Polyamine Therapy Restrains Kidney Cyst Growth in an Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney DiseaseSemantic proximity Read

Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease.Semantic proximity Read

Role of indoleamine 2,3-dioxygenase in health and diseaseSemantic proximity Read

Identification and Validation of Tryptophan Metabolism–Related Genes in Diabetic Kidney Disease and Construction of a Clinical Prediction ModelSemantic proximity Read

The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It ComplicatedSemantic proximity Read

Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosisSemantic proximity Read

Metabolite Genome-Wide Association Study for Indoleamine 2,3-Dioxygenase Activity Associated with Chronic Kidney Disease.Semantic proximity Read

Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosisSemantic proximity Read

Indoleamine 2,3-Dioxygenase 2 (IDO2): The Protein That Lived TwiceSemantic proximity Read

Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and diseaseSemantic proximity Read

IDO1 promotes CSFV replication by mediating tryptophan metabolism to inhibit NF-κB signalingSemantic proximity Read

Immune Checkpoint Activity Regulates Polycystic Kidney Disease ProgressionSemantic proximity Read