Article

Inherited DNA damage generates multi-allelic mutations in <i>C. elegans</i>

2026-08-28

Abstract excerpt

Exogenous and endogenous mutagens generate a wide variety of DNA lesions, including bulky adducts, chemical modifications, and single- or double-stranded breaks. A phenomenon called "lesion segregation," in which lesions evade repair and persist for multiple cell divisions, has recently been documented in tumors and healthy somatic tissues from mice and humans, respectively. Persistent lesions can generate multi-a...

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Literature Corpus work: a9dc81b7-2523-58f9-96e6-c63095e45cdb
DOI: 10.64898/2026.08.26.747097

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