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Article

Mutational signatures are jointly shaped by DNA damage and repair.

Nature communications - 1 May 2020

Volkova Nadezda V, Meier Bettina, González-Huici Víctor, Bertolini Simone, Gonzalez Santiago, Vöhringer Harald, Abascal Federico, Martincorena Iñigo, Campbell Peter J, Gartner Anton, Gerstung Moritz

Abstract excerpt

Cells possess an armamentarium of DNA repair pathways to counter DNA damage and prevent mutation. Here we use C. elegans whole genome sequencing to systematically quantify the contributions of these factors to mutational signatures. We analyse 2,717 genomes from wild-type and 53 DNA repair defective backgrounds, exposed to 11 genotoxins, including UV-B and ionizing radiation, alkylating compounds, aristolochic...

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Identifiers

PMID: 32358516
DOI: 10.1038/s41467-020-15912-7
PMCID: PMC7195458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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