Article
High direct estimate of the mutation rate in the mitochondrial genome of Caenorhabditis elegans.
Science (New York, N.Y.) - 29 Sept 2000
Denver D R, Morris K, Lynch M, Vassilieva L L, Thomas W K
Abstract excerpt
Mutations in the mitochondrial genome have been implicated in numerous human genetic disorders and offer important data for phylogenetic, forensic, and population genetic studies. Using a long-term series of Caenorhabditis elegans mutation accumulation lines, we performed a wide-scale screen for mutations in the mitochondrial genome that revealed a mutation rate that is two orders of magnitude higher than...
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