Article
Mitochondrial oxidative stress can lead to nuclear hypermutability.
Mechanisms of ageing and development - 1 Jun 2004
Hartman Phil, Ponder Rebecca, Lo Herng-Hsiang, Ishii Naoaki
Abstract excerpt
Reactive oxygen species (ROS) are generated in mitochondria and are thought to be important in aging, carcinogenesis, and the development of other pathologies. We now provide direct experimental evidence linking mitochondrial ROS generation to the induction of nuclear DNA damage and subsequent mutagenesis of a chromosomal gene. Specifically, we demonstrate that the mev-1 mutant of Caenorhabditis elegans has...
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