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Beyond Genetics: Metastasis as an Adaptive Response in Breast Cancer

3 Jun 2022

Abstract excerpt

Metastatic disease represents the primary cause of breast cancer (BC) mortality, yet it is still one of the most enigmatic processes in the biology of this tumor. Metastatic progression includes distinct phases: invasion, intravasation, hematogenous dissemination, extravasation and seeding at distant sites, micro-metastasis formation and metastatic outgrowth. Whole-genome sequencing analyses of primary BC and...

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PMID: 35682953
DOI: 10.3390/ijms23116271

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