Article
Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer.
Disease models & mechanisms - 29 May 2018
Johnstone Cameron N, Pattison Andrew D, Gorringe Kylie L, Harrison Paul F, Powell David R, Lock Peter, Baloyan David, Ernst Matthias, Stewart Alastair G, Beilharz Traude H, Anderson Robin L
Abstract excerpt
Triple-negative breast cancer (TNBC) represents 10-20% of all human ductal adenocarcinomas and has a poor prognosis relative to other subtypes. Hence, new molecular targets for therapeutic intervention are necessary. Analyses of panels of human or mouse cancer lines derived from the same individual that differ in their cellular phenotypes but not in genetic background have been instrumental in defining the...
Topics
- Animals
- Bone Morphogenetic Protein 4
- Cattle
- Cell Cycle
- Cell Line, Tumor
- Cystatin M
- DNA Copy Number Variations
- DNA Methylation
- DNA, Neoplasm
- Gene Expression Profiling