Article

Patient-derived organoid xenografts reveal the multifaceted role of the lncRNA <i>MALAT1</i> in breast cancer progression

2026-04-03

Abstract excerpt

Long non-coding RNAs (lncRNAs) have emerged as key regulators of tumor biology, however, thus far none have translated to cancer therapies. The lncRNA MALAT1 is overexpressed in more than 20 cancers, including breast cancer and has been shown to function via various mechanisms in a context-dependent manner, in 2D cell lines and mouse models. However, its functional role and therapeutic potential have not been eva...

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Literature Corpus work: 4748e724-cb20-59d4-a474-ce02a8f8200a
DOI: 10.64898/2026.04.02.716096

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