Article

An annotated biobank of triple negative breast cancer patient-derived xenografts featuring treatment-naïve and longitudinal samples throughout neoadjuvant chemotherapy

2024-11-28

Abstract excerpt

<h4>SUMMARY</h4> Triple negative breast cancer (TNBC) that fails to respond to neoadjuvant chemotherapy (NACT) can be lethal. Developing effective strategies to eradicate chemoresistant disease requires experimental models that recapitulate the heterogeneity characteristic of TNBC. To that end, we established a biobank of 92 orthotopic patient-derived xenograft (PDX) models of TNBC from the tumors of 75 patients...

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Literature Corpus work: bddf6ed0-0262-50c2-9b3b-8daa720c3abd
DOI: 10.1101/2024.11.25.625287

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