Article

Structural insights into the mechanism of the human SGLT2–MAP17 glucose transporter

2023-01-23

Abstract excerpt

Selective sodium-glucose cotransporter 2 (SGLT2) plays an important role in glucose reabsorption. SGLT2 inhibitors suppress glucose reabsorption from the kidneys, thus reducing blood glucose levels in type 2 diabetes patients. We and other groups have developed several SGLT2 inhibitors starting from a natural product, phlorizin, but their action mechanisms remain unknown. Here, we elucidated the physiological hSGL...

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Literature Corpus work: 5f0863b4-b5f6-5942-9568-a9833ffeee56
DOI: 10.1101/2023.01.23.524988

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