Article
Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population.
Endocrine journal - 1 Jan 2015
Yan Yu-Xiang, Wu Li-Juan, Zhang Jie, Wang Shuo, Wang Wei, Dong Jing, He Yan
Abstract excerpt
MicroRNA (miRNA) related genetic variation may change miRNA binding affinity and mRNA expression levels of the target genes, thus leading to altered metabolic parameters. This study explored the influence of let-7 related single nucleotide polymorphisms (SNPs) on individual susceptibility to metabolic syndrome (MetS) in a Chinese population. Seven SNPs located at the pri-let-7 gene region, pre-let-7 gene region...
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