Article
The polymorphism in the let-7 targeted region of the Lin28 gene is associated with increased risk of type 2 diabetes mellitus.
Molecular and cellular endocrinology - 15 Aug 2013
Zhang Jie, Zhang Longyi, Fan Runping, Guo Nengneng, Xiong Chunhui, Wang Lin, Jin Sheng, Li Wei, Lu Jianxin
Abstract excerpt
Genetic polymorphisms in the miRNAs pathway of the pathogenesis of disease might contribute to the risk of disease. However, it is unclear whether these polymorphisms about miRNAs are associated with the risk of type 2 diabetes mellitus (T2DM). We performed a case-control study to investigate two polymorphisms in the let-7/Lin28 pathway based on 588 T2DM patients and 588 age and sex matched controls. The results...
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