Article

LRRK2 mutation alters behavioral, synaptic and non-synaptic adaptations to acute social stress

2020-02-26

Abstract excerpt

Parkinson’s disease (PD) risk is increased by stress and certain gene mutations, including the most prevalent PD-linked mutation LRRK2 -G2019S. Both PD and stress increase risk for psychiatric symptoms, yet it is unclear how PD-risk genes alter neural circuitry in response to stress that may promote psychopathology. Here we show significant differences between adult G2019S knockin and wildtype (wt) mice in stress...

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Literature Corpus work: 477b5898-47af-5b3f-83dd-1097c554a4e4
DOI: 10.1101/2020.02.25.965194

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