Article

Parkinson’s LRRK2-G2019S risk gene mutation drives sex-specific behavioral and cellular adaptations to chronic variable stress

2024-06-08

Abstract excerpt

Anxiety is a psychiatric non-motor symptom of Parkinson’s that can appear in the prodromal period, prior to significant loss of brainstem dopamine neurons and motor symptoms. Parkinson’s-related anxiety affects females more than males, despite the greater prevalence of Parkinson’s in males. How stress, anxiety and Parkinson’s are related and the basis for a sex-specific impact of stress in Parkinson’s are not clea...

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Literature Corpus work: 021d942e-3ed7-5d38-9fe4-446fedb1b9d4
DOI: 10.1101/2024.06.05.597647

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